The odontoblast - a multifunctional cell
The most recognized function odontoblasts is the formation and maintenance of the dentin. Like many other fabrics-supporting cells, odontoblasts also contribute to the host defense. Aligning the periphery of pulp cellular expansion into the dentin they are thus in a unique position of being the first cell of the face and respond to the harmful elements input dentin of the oral environment (Fig. 2.4). To call odontoblasts create and issue a lot of molecules, which can help to defeat the invading microorganisms. Answer leads to activation of specific receptors on the adjacent cells, blood vessels, nerves and on odontoblast itself (Advanced concept 2.1). Thus, odontoblasts, together with a local resident protection of cells and blood-borne invasion cells have a wide repertoire of response patterns and play an important role in the activation of both the innate and adaptive immune response pulp (Fig. 2.5).
Advanced concepts 2.1 the Role of the odontoblasts in the tooth pulp immunity
Odontoblasts come with a lot of receptors that allow you to recognize and respond to the microbial items and thus prevent the immune system.
Thus, several members of the Toll-receptor family were determined on the odontoblasts (19, 23). When you activate these receptors production of proinflammatory cytokines and chemokines is initiated; these, in turn, recruit immune cells. Recent observations show that odontoblasts more powerful attractant than the tooth pulp fibroblasts in this respect (67). Odontoblasts may also issue of antimicrobial peptides with the possibility of direct killing of Gram-positive and Gram-negative bacteria (18). Odontoblasts in addition to respond to proinflammatory cytokines, allocated adjacent resident of the cells and the invasion of the cells of the immune system
. The specific substances that regulate the permeability of blood vessels and angiogenesis has also released on microbial problems (70). Consequently, strategic peripheral position odontoblast and its varied range of models of response make the cell tractor pulp defense to both externally and internally derived adverse effects. ..