1. Chronic inflammation is long lived outside the control of the inflammatory response that lasts more than a few weeks.
a. This pathological condition characterized by active inflammation, tissue destruction, and attempts to repair.
B. Warning signs of acute inflammation missing in chronic inflammation, such as periodontitis-and the problem may go unnoticed host (the patient). Clinically, the pain is often missing.
2. The inflammatory response is another important task: to immediately respond to destroy pathogens in damaged tissue, before they can spread to other areas of the body.
a. Chronic inflammation occurs when the body is not able to eliminate the infection. At this stage, the invading microorganisms are permanent and stimulate exaggerated reaction to the host's immune system.
B. In their desire to protect the body, the inflammatory response is to destroy as much tissue as necessary to achieve this goal.
c. In those cases, when the inflammation becomes chronic inflammation may become so strong that it deals damage to body tissues.
In this case, in periodontitis.
B. Chronic Inflammation,
1. The accumulation of macrophages characterized by chronic inflammation.
2. Macrophages to absorb and digest microorganisms.
3. Leukocytes produces a variety of inflammatory mediators, including IL-1, TNF-alpha, and prostaglandins that perpetuate the inflammatory response (Fig. 8-15).
a. One of the principle cytokines secreted by macrophages - TNF-alpha . Data show that TNF-alpha contributes to the tissue destruction that is characterized by chronic inflammation (table. 8-2).
B. In fact, tissue damage is a sign of chronic inflammation.
4. If the infection persists, inflammation can last several months or even years.
5. Chronic inflammation is abnormal and doesn't do any good to the body. Chronic inflammation-control response that can destroy healthy tissue and cause more harm than the original problem.
a. Leave it without attention, hyperactivity inflammatory response can even begin to attack healthy tissue.
B. Chronic inflammation is associated with a number of disease States, including asthma, rheumatoid arthritis, diabetes, atherosclerosis, gingivitis and periodontitis.